The Alkaloids of Cinchona
نویسنده
چکیده
?n observations on the action o alkaloids in causing disappearance o parasites during an acute attack. Reports were received: , 7 (1) From Colonel Harvey who tinted 7 cases of benign tertian malaria with q bisulphate, 10 grains for 70 kilogrammes 'body weight. The drug was dissolved m dilute sul Phuric acid, one dose was given before break fast and one before the evening mea . Eleven patients were treated wi qui
منابع مشابه
Transformation of Cinchona alkaloids into 1-N-oxide derivatives by endophytic Xylaria sp isolated from Cinchona pubescens.
The microbial transformation of four Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) by endophytic fungi isolated from Cinchona pubescens was investigated. The endophytic filamentous fungus Xylaria sp. was found to transform the Cinchona alkaloids into their 1-N-oxide derivatives.
متن کاملBioproduction of Cinchona alkaloids by the endophytic fungus Diaporthe sp. associated with Cinchona ledgeriana.
We report that an endophytic filamentous fungus species of the genus Diaporthe isolated from Cinchona ledgeriana (Rubiaceae) produces Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) upon cultivation in a synthetic liquid medium. This study provides evidence that Cinchona alkaloids are produced not only in Cinchona plant cells, but also in the endophytic microbe cells, and ...
متن کاملAn Overview of Cinchona Alkaloids in Chemistry
Cinchona alkaloids (Figure 1.1), isolated from the bark of several species of cinchona trees, are the organic molecules with the most colorful biography [1]. Their history dates back to the early seventeenth century when they were first introduced into the European market after the discovery of the antimalarial property of cinchona bark and the subsequent isolation of its active compound, quini...
متن کاملCyclodextrins as carriers for cinchona alkaloids: a pH-responsive selective binding system.
A series of cyclodextrin-cinchona alkaloid inclusion complexes were prepared from beta-cyclodextrin, heptakis(2,6-di-O-methyl)-beta-cyclodextrin and heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin and four cinchona alkaloids in ca. 90% yields, and their inclusion complexation behavior was investigated at pH 7.2 and 1.5 by means of fluorescence, UV/Vis and 2D NMR spectroscopy. The results showed ...
متن کاملPackaging the Alkaloids of Cinchona Bark in Combination with Etoposide in Polymeric Micelles Nanoparticles
Today, cancer remains one of the major diseases that lead to death. The main obstacle in chemotherapy as a main cancer treatment is the toxicity to normal cells due to Multidrug Resistance (MDR) after the use of anticancer drugs. Proposed solution to overcome this problem is the use of MDR efflux inhibitor of cinchona alkaloids which is delivered together with anticancer drugs encapsulated in t...
متن کاملStudies on the Chemotherapy of the Human Malarias. Iii. the Physiological Disposition and Antimalarial Activity of the Cinchona Alkaloids.
The relative effectiveness of the various cinchona alkaloids in the treatment of malaria has been the subject of numerous investigations since the meeting of the Madras Commission in 1868 (1). Without exception, studies undertaken prior to the recent war involved the appraisal of the comparative antimalarial activities of quinine, quinidine, cinchonine and cinchonidine on the basis of the oral ...
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